School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Australia
INPEC node since 2012
The group’s research theme is protein structure and function, with the emphasis on understanding the structural basis of intra- and intermolecular interactions formed by these macromolecules and inferring function from structure. The biological focus is on proteins involved in infection and immunity. The goal of the research is to use structural and molecular information to understand the molecular and cellular functions of proteins, validate proteins as therapeutic targets or biotechnological products, and to design new therapeutics and biotechnological applications. The primary techniques used in the laboratory are X-ray crystallography and electron microscopy, combined with a plethora of other molecular biology, biophysical, structural and computational techniques.
Keywords: epigenetics, chromatin, nucleosome, X-ray crystallography, histone modifying enzymes