Marco Malten

Enzyme Discovery, Novozymes A/S, Lyngby, Denmark

 

INPEC node since 2026

 

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Novonesis is a global leader in the development of enzymes for industrial applications, playing a strong role in advancing sustainable biosolutions across diverse industries, eg. 2nd generation biomass, animal feed and laundry. Our research is focused on finding and engineering enzymes for industrial applications. To achieve this, we employ a combination of cutting-edge computational and experimental approaches, including rational design, directed evolution, machine learning and artificial intelligence driven tools. 

 

I focused over the last two decades on optimizing learning loops in running protein engineering campaigns often stabilizing detergent enzymes. In laundry detergents enzymes are playing a crucial role to remove stains. These enzymes need to be stable in diverse liquid detergent formulations. My key responsibilities include leading the design and proposal of innovative enzyme engineering strategies, overseeing the molecular biological generation and robotic screening of enzyme variants and libraries. Advanced data analytics such as mutational effect analysis and machine learning guide the development of optimized enzyme candidates. AI driven tools are revolutionizing protein engineering, so testing, applying and developing these is also a key interest. 

 

Keywords: nenzyme engineering and screening, industrial application, detergent enzymes, protein stability, learning from complex datasets, protein engineering flow optimization.