Alberto Marina

Instituto de Biomedicina de Valencia

Javier Sancho

Institute of Biocomputation and Physics of Complex Sustems, University of Zaragoza, Zaragoza, Spain

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INPEC node since 2017

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We study protein stability using all kind of wet and computational approaches. We try to understand the physics involved and to develop quantitative tools for the rational design of protein stability. We practise target-oriented drug discovery combining high through put screening of chemical libraries, structural determination of ligand-target complexes, medicinal chemistry and computational tools to increase complex affinity. We are working of the prediction of phenotypes for proteins carrying single-nucleotide variations. 

 

Keywords:protein stability and stabilization, target-based drug discovery, structural biology, biocomputation, genetic interpretation