Department of Biomolecular Sciences, Weizmann Institute, Rehovot, Israel
INPEC node since 2002
Specific protein-protein interactions form a major part of the basic organization of living cells. The structure of a protein complex holds information about the relative mutual organization of two proteins in a frozen state, but not about the kinetic or thermodynamic parameters that are central to their function. For many years I have been interested in understanding the relationships between the structures of transient protein-protein interactions and their binding activity. To address this, I adopted a multidisciplinary approach including: wet biophysical bench work, protein-design and engineering and bioinformatics and applied the gained knowledge and techniques to address biological questions.
Keywords: protein-protein interaction, Interferon, Signaling, proteins, protein-engineering, structure/function